Epigenetics and Bone Remodeling
نویسندگان
چکیده
منابع مشابه
Epigenetics and Chromatin Remodeling in Adult Cardiomyopathy
The manipulation of chromatin structure regulates gene expression and the flow of genetic information. Histone modifications and ATP-dependent chromatin remodeling together with DNA methylation are dynamic processes that modify chromatin architecture and profoundly modulate gene expression. Their coordinated control is key to ensuring proper cell commitment and organ development, as well as ada...
متن کاملBone Remodeling and Healing
To fulfill adequately their functions of support, sustentation and protection for the internal organs and guarantee blood calcium homeostasis, bone tissue is in constant remodeling. Alveolar bone, the primary support structure for teeth, is particularly subjected to continuous and fast remodeling associated with tooth eruption and positional adaptations, as well as with the functional demands o...
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Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person's individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critical genes. Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. ...
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Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA-associated silencing by small non-coding RNAs. All these mechanisms are crucial for normal development, differentiation and tissue-specific gene expre...
متن کاملnormAl bone remodelIng
Paget’s disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased os...
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ژورنال
عنوان ژورنال: Current Osteoporosis Reports
سال: 2017
ISSN: 1544-1873,1544-2241
DOI: 10.1007/s11914-017-0391-y